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BASC complex


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A multiprotein complex (BRCA1-associated genome surveillance complex) composed of BRCA1, tumour suppressors and the DNA damage repair proteins MSH2, MSH6, MLH1, ATM, BLM, and the MRN complex (MRE11, RAD50, and nibrin). It may coordinate the multiple activities required to maintain genomic integrity during DNA replication.

Subjects: Medicine and Health.


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