BCG vaccine

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The vaccine against tuberculosis prepared from live attenuated bovine tubercle bacilli using a method developed by the French microbiologists Léon Calmette (1863–1933) and Camile Guérin (1872–1961) in the late 1920s. Initial trials had catastrophic results because of contamination with virulent strains of tubercle bacilli and other organisms, but further trials demonstrated the safety and efficacy of BCG vaccine, and it has been widely used since the 1940s, now especially as part of vaccination regimens in low- and middle-income countries.

Subjects: Public Health and Epidemiology.

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