A miscellaneous group of oncogenes associated with B-cell lymphomas. Bcl-1 (295 aa) interacts with cyclin-dependent kinases and when translocated may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma, multiple myeloma, and parathyroid adenomas. Bcl-2 is an integral inner mitochondrial membrane protein (239 aa) that blocks the apoptotic death of pro-B-cells by controlling mitochondrial membrane permeability by acting on the VDAC porin channel. There are a family of Bcl-2-related proteins, some proapoptotic (Bax, Bad, Bak and Bok among others) or antiapoptotic (Bcl-2 itself, Bcl-xL, Bcl-w, and others). Bcl-2 family proteins are associated with various malignancies. Bcl-3 (446 aa) interferes with the binding of NFκB to DNA by acting as an IκB homologue and if translocated into immunoglobulin gene regions can cause B-cell chronic lymphocytic leukaemia. Bcl-6 (706 aa) is a transcriptional repressor. The bcl-2 homology domain 3 (BH3) is characteristic of proapoptotic proteins such as Bim, Bmf, Bik, Bad, Bid, Puma, Noxa, and Hrk.
Subjects: Medicine and Health — Chemistry.