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The region (breakpoint cluster region) of chromosome 22 that is involved in the Philadelphia chromosome translocation. BCR is one of the two genes in the BCR-ABL complex and encodes a 160-kD phosphoprotein (1281 aa, EC 7.11.1) associated with serine/threonine kinase activity. It is also a GTPase-activator for rac1 and cdc42.

Subjects: Medicine and Health.

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