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A protein (breast cancer antioestrogen resistance-3, novel SH2-containing protein 2, NSP2, 825 aa) that is expressed in breast carcinoma cells that have developed tamoxifen resistance. The mouse homologue (AND34, p130Cas-binding protein) is thought to be an adaptor protein that couples activated growth factor receptors to signalling molecules that regulate src-kinase activity and promote cell migration.

Subjects: Medicine and Health.

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