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A family of anion channels, probably calcium-sensitive chloride channels. Bestrophin 1 (585 aa), the protein that is defective in Best's disease, is localized to the basolateral plasma membrane of the pigmented retinal epithelium RPE. Three other related proteins (bestrophin-2, -3, and -4) share many structural features but have distinct tissue distributions.

Subjects: Medicine and Health — Chemistry.

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