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A highly anionic compound present in erythrocytes at about the same molar ratio as haemoglobin. It binds to deoxyhemoglobin and allosterically alters the molecule, reducing its oxygen affinity and facilitating oxygen release in capillaries. The concentration of BPG is regulated by bisphosphoglycerate mutase (EC, 259 aa) which catalyses its production; it is hydrolysed by bisphosphoglycerate phosphatase (EC, 254 aa).

Subjects: Medicine and Health.

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