Protein complexes (biogenesis of lysosome-related organelles complexes) involved in the biogenesis of specialized lysosome-related organelles such as melanosomes and platelet dense granules. Subunits of BLOC1 include pallidin, muted, dysbindin (dystrobrevin-binding protein 1), cappuccino, snapin, and others. BLOC-1 interacts with adaptor protein-3 (AP-3) to form complex that affects the targeting of SNARE and non-SNARE cargoes. BLOC-2 and BLOC-3 are related complexes. See Hermansky–Pudlak syndrome.
Subjects: Medicine and Health.