A family of multifunctional cytokines, the BMPs belong to the transforming growth factor β superfamily. Many are growth and differentiation factors (GDFs) and may be regulated by BMP-binding proteins such as noggin, chordin, and follistatin. The receptors are serine/threonine kinase receptors (types I and II) that link with MAD-related proteins. BMP2 and BMP3 (osteogenin) are involved in regulating bone formation; BMP4 acts during development as a regulator of mesodermal induction and is overexpressed in fibrodysplasia ossificans.
Subjects: Medicine and Health — Chemistry.