A polarized arrangement of chromosome ends at the periphery while the remaining chromatin fills the volume of the nucleus. This is the result of telomeres (q.v.) moving along the inner surface of the nuclear envelope during leptonema and eventually bunching together at the bouquet site. The tethering of telomeres to the nuclear periphery requires a specific meiotic telomere protein. In Saccharomyces cerevisiae this protein is encoded by a gene called Ndj1 (nondisjunction 1). Deletion of Ndj1 prevents bouquet formation and causes a delay in the pairing of homologues. See meiosis.
Subjects: Genetics and Genomics.