One of the neurotrophin family, a small basic protein (247 aa) that promotes the survival of neurons in or connected to the central nervous system. BDNF is a regulator of synaptic transmission and plasticity in adults and is important in long-term potentiation, long-term depression and some forms of short-term synaptic plasticity. Huntingtin upregulates transcription of BDNF and transport of BDNF-containing vesicles along microtubules. Polymorphisms in the BDNF gene are associated with susceptibility to bulimia nervosa 2 and anorexia nervosa 2.
Subjects: Medicine and Health — Chemistry.