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Genes associated with susceptibility to breast and ovarian cancer. Women with mutations in either of these genes have a 56–85% risk of developing breast cancer, and this form of the cancer tends to develop at a relatively young age. The risk of ovarian cancer is 36–66% in women with BRCA1 mutations and 10–20% with BRCA2. Targeted therapy specific to these mutations using a PARP inhibitor is undergoing investigation.

Subjects: Medicine and Health — Chemistry.

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