breast cancer susceptibility genes

'breast cancer susceptibility genes' can also refer to...

breast cancer susceptibility genes

breast cancer susceptibility genes

Gene–gene interactions in breast cancer susceptibility

Acetyl-CoA carboxylase α gene and breast cancer susceptibility

‘Other’ breast cancer susceptibility genes: searching for more holy grail

RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

Variants in DNA double-strand break repair genes and breast cancer susceptibility

Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility

Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case–control study in Taiwan

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer

Low Proportion of BRCA1 and BRCA2 Mutations in Finnish Breast Cancer Families: Evidence for Additional Susceptibility Genes

Characterization of Arabidopsis thaliana ortholog of the human breast cancer susceptibility gene 1: AtBRCA1, strongly induced by gamma rays

Use of deep whole-genome sequencing data to identify structure risk variants in breast cancer susceptibility genes


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Genes that when mutated greatly increase the susceptibility of heterozygous women to breast cancer. The first gene, BRCA1, resides at 17q21. It was cloned in 1994 and shown to encode a protein containing 1,863 amino acids. BRCA2 resides at 13q12–13. It was cloned in 1995 and is now known to encode a protein containing 3,418 amino acids. Together, BRCA1 and BRCA2 are responsible for most cases of hereditary breast cancer. BRCA1 also increases the risk of ovarian cancer, but BRCA2 does not. The BRCA1 protein contains two zinc finger domains and is therefore believed to function as a transcription factor. See Chronology, 1994, Miki et al.; 1995, Wooster et al.; anti-oncogene, Mendelian Inheritance in Man (MIM), zinc finger protein.

Subjects: Genetics and Genomics.

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