A family of adaptor proteins containing BAR domains (see BAR proteins). Bridging integrator 1 (BIN1, myc box-dependent-interacting protein 1, 593 aa) is an amphiphysin-like protein that may be involved in regulation of synaptic vesicle endocytosis and may act as a tumour suppressor. Mutations are the cause of autosomal recessive centronuclear myopathy (autosomal recessive myotubular myopathy). Bridging integrator 2 (BRAP1, breast cancer-associated protein 1, 565 aa) is preferentially expressed in haematopoietic tissues. Bridging integrator 3 (253 aa) has a role in the organization of F-actin during cytokinesis.
Subjects: Medicine and Health.