Overview

bromodomain


'bromodomain' can also refer to...

bromodomain

bromodomain

Bromodomains as therapeutic targets in cancer

SP040BET BROMODOMAIN INHIBITION AMELIORATES EXPERIMENTAL INFLAMMATION IN THE KIDNEY

SP048THE BET BROMODOMAIN INHIBITOR JQ1 DIMINISHED RENAL FIBROSIS

Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD

Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase–dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes

EG-04DEVELOPMENT OF HIGHLY POTENT, SELECTIVE BET BROMODOMAIN INHIBITORS THAT ARE CNS PENETRANT AND EFFECTIVE IN RODENT MODELS OF BRAIN CANCER

255 Microarray Analysis Maps Global Effects of Epigenetic Bromodomain Inhibitor JQ1 on Gene Expression in Transforming Growth Factor-β-Stimulated Adult Lung Fibroblasts

Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function

The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3′-UTR truncation in round spermatids

O7.3BET-bromodomain (BRD) inhibitor OTX015: Final results of the dose-finding part of a phase I study in hematologic malignancies

SP071APABETALONE (RVX-208), A SELECTIVE BROMODOMAIN AND EXTRA-TERMINAL (BET) PROTEIN INHIBITOR, DECREASES ABUNDANCE AND ACTIVITY OF COMPLEMENT PROTEINS IN VITRO, IN MICE AND IN CLINICAL STUDIES

 

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A conserved domain (~70 aa) that binds to acetylated lysine residues such as those on the N-terminal tails of histones. Bromodomains are found in DNA-associated proteins from a wide range of organisms and are thought to be involved in protein–protein interactions in transcriptional activation complexes.

Subjects: Chemistry — Medicine and Health.


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