Brugada syndrome

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An autosomal dominant disorder (sudden unexplained nocturnal death syndrome). Type 1 is caused by mutation in the pore-forming α subunit of voltage-gated sodium channel NaV1.5, leading to cardiovascular problems including idiopathic ventricular fibrillation and the risk of sudden cardiac arrest. Type 2 is caused by a defect in the GPD1L gene (glycerol-3-phosphatase dehydrogenase 1-like) which affects the properties of the ion channel mutated in type 1.

Subjects: Medicine and Health.

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