Overview

calcineurin


Show Summary Details

Quick Reference

A phosphatase enzyme that plays a crucial role in relaying intracellular signals following activation of immune cells, particularly lymphocytes (T cells and B cells). It is itself activated by the rise in intracellular concentration of calcium ions that follows stimulation of receptors on the cell surface. Calcineurin is inhibited by the drugs ciclosporin and tacrolimus, which is the basis for their use as immunosuppressants to inhibit T-cell activity, for example in preventing rejection of tissue grafts.

Subjects: Chemistry.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.