Members of the family of calcium-binding proteins containing an EF-hand motif that includes calmodulin, parvalbumin, troponin C, and S100 protein. Calbindin 1 (261 aa) is found in primate striate cortex and other neuronal tissues. Calbindin-positive neurons in the thalamus are thought to play a role in arousal by stimulating the cortex. Calbindin 2 (calretinin) is similar to calbindin 1 but slightly larger (271 aa) and found in cerebellar Purkinje cells. Calbindin 3 (intestinal calcium-binding protein, 79 aa) is found in the intestine and is induced by vitamin D.
Subjects: Medicine and Health.