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Campbell model of lambda integration


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A hypothesis that explains the mechanism of integration of phage lamda into the E. coli host chromosome. According to the model, linear lambda DNA is first circularized. Then prophage integration occurs as a physical breakage and reunion of phage and host DNA molecules precisely between the bacterial DNA site for phage attachment and a corresponding site in the phage DNA. See Chronology, 1962, Campbell.

Subjects: Genetics and Genomics.


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