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'camptothecin' can also refer to...


Self-defensive nano-assemblies from camptothecin-based antitumor drugs

Spatial organization of topoisomerase I‐mediated DNA cleavage induced by camptothecin–oligonucleotide conjugates

In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells

Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination

The involvement of chromatin condensation in camptothecin-induced chromosome breaks in G0 human lymphocytes

Variations in the secondary metabolite camptothecin in relation to tissue age and season in Camptotheca acuminata

Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3

Characterization of the antitumor-promoting activity of camptothecin in SENCAR mouse skin

The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription

Separation of 9-Methoxycamptothecin and Camptothecin from Nothapodytes foetida by Semipreparative HPLC

Differential induction of Leishmania donovani bi-subunit topoisomerase I–DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I

The Utility of Camptothecin as a Synergist of Bacillus thuringiensis var. kurstaki and Nucleopolyhedroviruses Against Trichoplusia ni and Spodoptera exigua

Camptothecin Biosynthetic Genes in Hairy Roots of Ophiorrhiza pumila: Cloning, Characterization and Differential Expression in Tissues and by Stress Compounds

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation

DNA demethylation protects from cleavable complex stabilization and DNA strand breakage induced by the topoisomerase type I inhibitor camptothecin

Isolation of camptothecin-sensitive Chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group

Distribution of camptothecin-induced break points in Chinese hamster cells treated in late S and G2 phases of the cell cycle


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A cytotoxic alkaloid that inhibits DNA topoisomerase I, originally isolated from Camptotheca acuminata (cancer tree, tree of life). Various derivatives such as CPT-11 (Irinotecan) are used as antitumour drugs.

Subjects: Medicine and Health.

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