One of the gelsolin family of proteins (macrophage capping protein, MCP, gCap39, 348 aa) that binds to the barbed ends of microfilaments. Has ~50% sequence homology with gelsolin, and like gelsolin responds to calcium and to phosphoinositides; unlike gelsolin it does not sever filaments. Originally isolated from macrophages but widely distributed and is the only gelsolin-related actin-binding protein found in both nucleus and cytoplasm. It is also secreted into plasma, though does not have a signal sequence. Not the same as capZ, though functionally similar.
Subjects: Medicine and Health.