A protein motif (caspase activation and recruitment domain) found in a wide array of proteins, particularly those involved in inflammation and apoptosis, where it is involved in the formation of multiprotein complexes through interaction with other CARD domains. Many of the CARD domain-containing proteins are members of the MAGUK family, e.g. CARD4 (nucleotide-binding oligomerization domain protein 1, Nod-1, 953 aa) is expressed abundantly in adult heart, spleen, and lung. It is also found in numerous cancer cell lines and fetal tissues. The protein interacts with the CARD domain of RICK and is a potent activator of NFκB. CARD12 (CARD, LRR, and NACHT domain-containing protein, CLAN, ICE protease-activating factor, IPAF, 1024 aa with shorter isoforms) is ubiquitously expressed and has a role in promoting apoptosis. At least seven other CARDs are known. CARD 8 is cardinal.
Subjects: Medicine and Health — Chemistry.