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An adaptor protein (p130Cas, Crk associated protein, breast cancer anti-oestrogen resistance protein 1, 870 aa) that has central coordinating role in tyrosine-kinase-based signalling related to cell adhesion and implicated in induction of cell migration and tumour invasiveness. When tyrosine-phosphorylated, Cas acts as a docking protein for binding SH2 domains of src-family kinases. One of a family of adaptor proteins that includes human enhancer of filamentation 1 (HEF1) and src-interacting protein (Sin)/Efs.

Subjects: Medicine and Health.

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