catabolite repression

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The reduction or cessation of synthesis of enzymes involved in catabolism of sugars such as lactose, arabinose, etc., when bacteria are grown in the presence of glucose. The enzyme adenyl cyclase is inhibited by glucose from converting ATP to cyclic adenosine monophosphate (cAMP); cAMP must complex with catabolite activator protein (CAP) in order for RNA polymerase to bind to promoters of genes responsible for enzymes capable of catabolizing sugars other than glucose. Therefore, in the presence of glucose, less CAP protein is available to facilitate the transcription of mRNAs for these enzymes.

Subjects: Chemistry — Genetics and Genomics.

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