A so-called ‘licensing protein’ (Cdc10-dependent transcript 1, 546 aa) that binds to the origin of DNA replication and facilitates the binding of cell division cycle 6 (Cdc6) and mini-chromosome maintenance proteins (Mcms). The Drosophila homologue is Double-parked (Dup). Once replication has been initiated at the end of G1, Cdt1 is exported out of the nucleus and degraded. See geminin.
Subjects: Medicine and Health.