Genes first isolated from yeast which encode proteins that control critical steps in the cell division cycle. An example of such a protein is Cdc 14, a phosphatase that is localized in the nucleolus (q.v.). When the contents of the nucleolus are dispersed in late anaphase, this enzyme digests mitotic cyclins. See Chronology, 1973, Hartwell et al.; cyclins.
Subjects: Genetics and Genomics.