The production of viable hybrid somatic cells following experimentally induced cell fusion (q.v.). In the case of interspecific hybrids, there is a selective elimination of chromosomes belonging to one species during subsequent mitoses. Eventually, cell lines can be produced containing a complete set of chromosomes from one species and a single chromosome from the other. By studying the new gene products synthesized by the hybrid cell line, genes residing in the single chromosome can be identified. See Chronology, 1960, Barski et al., HAT medium, hybridoma, syntenic genes.
Subjects: Genetics and Genomics.