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cerebral amyloid angiopathy


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A disease of small blood vessels in the brain in which there are deposits of amyloid protein in the vessel walls leading to stroke, brain haemorrhage, or dementia. The commonest form is associated with ageing but there are genetic forms. In the Dutch and Flemish types there is mutation in amyloid precursor protein, in the Icelandic type mutation in cystatin C, in the British type the mutation is in integral membrane protein 2B (266 aa). It can also be associated with high-density lipoprotein deficiency caused by mutation in the ABCA1 gene.

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