cerebral cavernous malformations

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Autosomal dominant disorders characterized by venous sinusoids that predispose to intracranial haemorrhage. Cerebral cavernous malformation type 1 (CCM1) can be caused by mutation in the KRIT1 gene, CCM2 by mutation in the CCM2 gene encoding malcaverin, and CCM3 by mutation in the PDCD10 gene (programmed cell death 10).

Subjects: Medicine and Health.

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