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cerulenin


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(2R,3S)‐epoxy‐4‐oxo‐7E,10E‐dodecadienamide; an antifungal antibiotic isolated from Cephalosporium caerulens and other sources. It inhibits fatty‐acid biosynthesis by binding with 3‐oxoacyl‐[acyl carrier protein] synthase (see fatty acid synthase complex) and also interferes with sterol biosynthesis by inhibiting hydroxymethylglutaryl‐CoA synthase activity.

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Subjects: Chemistry.


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