checkerboard assay

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An improved methodology for investigating the potential chemotactic or chemokinetic properties of substances using a Boyden chamber assay but with positive, negative, and zero-gradient conditions. In nongradient conditions a chemokinetic effect will enhance leucocyte penetration into filters; only if the movement in gradient conditions is greater is there evidence for gradient perception and directed movement (chemotaxis).

Subjects: Medicine and Health.

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