checkpoint kinase

'checkpoint kinase' can also refer to...

checkpoint kinase

Checkpoint kinase 1 negatively regulates somatic hypermutation

Protein kinase C controls activation of the DNA integrity checkpoint

Identification of XAF1 as a novel cell cycle regulator through modulating G2/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer

A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA

Involvement of fission yeast Clr6-HDAC in regulation of the checkpoint kinase Cds1

Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

P6.14Identification of selective inhibitors of the spindle assembly checkpoint kinase TTK (Mps1) for treatment of triple negative breast cancer

Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM

Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass

Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication


375PDPhase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine (gem) in patients (pts) with refractory solid tumors

117PDClinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas

A phase II study of the cell cycle checkpoint kinases 1 and 2 (CHK1/2) inhibitor (LY2606368; prexasertib) in sporadic triple negative breast cancer (TNBC)

Expression pattern of immune checkpoint-associated molecules in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors


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Quick Reference

A cell‐cycle checkpoint protein kinase that is activated in response to DNA damage. Its action prevents the cell from entering mitosis.

Subjects: Chemistry.

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