A family of GTPase-activating proteins for rac that have high affinity for phorbol esters and diacylglycerol. N-chimerin (alpha-chimerin, 459 aa) may be important in neuronal signal-transduction mechanisms. Mutations in (alpha-chimerin are responsible for Duane retraction syndrome 2. Beta-chimerin (468 aa) is found mostly in the brain and pancreas, and expression is much reduced in malignant gliomas.
Subjects: Chemistry — Medicine and Health.