1. The C-terminus of Hsp70-interacting protein (C-terminus of Hsp70-interacting protein, STIP1 homology, and U box-containing protein 1, EC 6.3.2.-, E3 ubiquitin-protein ligase CHIP, 303 aa) A cochaperone and ubiquitin ligase that modulates the activity of several chaperone complexes, including Hsp70, Hsc70, and Hsp90.
2. Aquaporin-1 (aquaporin-CHIP, CHIP-28, 269 aa), a transmembrane protein that forms a water-specific channel in erythrocytes and epithelial cells of the kidney proximal tubule. See aquaporins.