A member of the bisguanide group of antiseptics used as a mouthwash, gel, spray, varnish, or irrigant. It is effective at inhibiting plaque regrowth and the development of gingivitis. It has a bitter taste and can deposit an extrinsic brown stain on the teeth. Trade names: Corsodyl, Peridex, PerioGard. It has been incorporated into a biodegradable hydrolysed gelatine chip (trade name: Periochip) which biodegrades when placed in a gingival pocket, releasing the active ingredient over a period of about 10 days.
Kolahi J., Soolari A. Rinsing with chlorhexidine gluconate solution after brushing and flossing teeth: a systematic review of effectiveness. Quintessence Int 2006;37(8):605–12.Cosyn J., Wyn I. A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2006;77(2):257–64.