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chromosome bridge


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A bridge formed between the separating groups of anaphase chromosomes because the two centromeres of a dicentric chromosome are being drawn to opposite poles (see illustration). Such bridges may form as the result of single- or three-strand double-exchanges within the reverse loop of a paracentric inversion heterozygote (see inversion). They may also arise as radiation-induced chromosome aberrations (q.v.). Such chromosome bridges are always accompanied by acentric chromosome fragments. See breakage-fusion-bridge cycle.

Chromosome bridges (identified by arrows)

Subjects: Genetics and Genomics.


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