chronic granulomatous disease

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A disease, usually fatal in childhood, in which phagocytes are unable to produce the reactive oxygen species used to kill bacteria. The absence of the oxygen-dependent killing mechanism seriously compromises the primary defence system and there is recurrent infection. At least three mutations can cause the disease, the commonest being an X-linked defect in plasma membrane cytochrome (see phox).

Subjects: Chemistry — Medicine and Health.

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