Microtubule-associated proteins that link endocytic vesicles to microtubules. CLIP-1 (cytoplasmic linker protein-170, CAP-Gly domain-containing linker protein 1, Reed–Sternberg intermediate filament-associated protein, restin, 1427 aa) is highly expressed in Reed–Sternberg cells. CLIP-1 binds to growing ends of microtubules that have bound plus end-binding proteins such as EB1 and is part of the microtubule plus end tracking system that regulates microtubule dynamics. CLIP3 (CLIP-170 related 59-kDa protein, 547 aa) is also a cytoplasmic linker protein and is involved in trans-Golgi/endosome dynamics.
Subjects: Medicine and Health.