The complement-activating protein (CVF, 1642 aa) found in the venom of the monocled cobra Naja kaouthia. It is a structural and functional analogue of complement component C3 which will bind factor B and is then cleaved by factor D to form a C3/C5 convertase, CVF,Bb. Its potency is probably due to insensitivity to human C3b inactivator. It is used experimentally to deplete the complement system.
Subjects: Medicine and Health.