1. Cocaine- and amphetamine-regulated transcript protein. A hypothalamic neuropeptide (116 aa) associated with the actions of leptin and neuropeptide Y that has anorectic properties, inhibiting normal and starvation-induced feeding and blocking the feeding response induced by neuropeptide Y and regulated by leptin. It promotes neuronal development and survival in vitro. A defect in CART is associated with reduced resting energy expenditure and cosegregates with obesity phenotype.
2. ALX homeobox protein 1 (cartilage homeoprotein 1, CART-1, 326 aa), a paired homoebox transcription factor that may play a role in chondrocyte differentiation and may also influence cervix development. Functions as a repressor with the rat prolactin promoter in vivo.