cold agglutinins

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Antibodies (IgM) that react with blood groups I and i (precursors of the ABH and Lewis blood group substances), and agglutinate red blood cells on cooling, causing Raynaud's disease in vivo. Cold agglutinin disease is an extreme form in which there are high levels of IgM that cause haemolytic anaemia.

Subjects: Medicine and Health.

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