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A family of compounds, originally derived from the African bush willow tree Combretum caffrum, used in cancer chemotherapy where they inhibit tumour vascularization by binding to tubulin in endothelial cells. Synthetic variants are emerging with slightly different efficacy. Combretastatin A-4 is the most potent naturally occurring combretastatin and is currently (2009) in clinical trials as a combination therapy with carboplatin and paclitaxel for thyroid carcinoma.

Subjects: Medicine and Health.

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