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A multifunctional protein (copper metabolism MURR1 domain-containing protein 1, MURR1, 186 aa) that inhibits NFκB by affecting the association of NFκB with chromatin and has a copper metabolism (MURR1) gene domain. It is a candidate for diseases of copper deficiency (Menkes' disease) or copper accumulation (Wilson's disease). It is the archetype of a family of conserved proteins (COMM domain-containing 1–10) that form multimeric complexes and share the MURR1 domain which is an interface for protein–protein interactions.

Subjects: Medicine and Health.

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