connective tissue growth factor

Quick Reference

One of the CCN family of cysteine rich regulatory proteins (CTGF, 349 aa) that is secreted by vascular endothelial cells and stimulates the proliferation and differentiation of chondrocytes; induces angiogenesis; promotes cell adhesion of fibroblasts, endothelial, and epithelial cells; and binds to insulin-like growth factor, transforming growth factor (TGFβ1), and bone morphogenetic protein-4. It enhances fibroblast growth factor-induced DNA synthesis. Connective tissue growth factor-like (CTGFL/WISP-2, Wnt-1-induced signalling pathway protein-2, CCN5, 250 aa) is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. It promotes adhesion of osteoblasts, inhibits the binding of fibrinogen to integrin receptors, and inhibits osteocalcin production.

Subjects: Medicine and Health — Chemistry.

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