One of the CCN family of cysteine rich regulatory proteins (CTGF, 349 aa) that is secreted by vascular endothelial cells and stimulates the proliferation and differentiation of chondrocytes; induces angiogenesis; promotes cell adhesion of fibroblasts, endothelial, and epithelial cells; and binds to insulin-like growth factor, transforming growth factor (TGFβ1), and bone morphogenetic protein-4. It enhances fibroblast growth factor-induced DNA synthesis. Connective tissue growth factor-like (CTGFL/WISP-2, Wnt-1-induced signalling pathway protein-2, CCN5, 250 aa) is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. It promotes adhesion of osteoblasts, inhibits the binding of fibrinogen to integrin receptors, and inhibits osteocalcin production.
Subjects: Medicine and Health — Chemistry.