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Corey-Pauling rules


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A set of rules, formulated by Robert Corey and Linus Pauling, that govern the secondary nature of proteins. The Corey-Pauling rules are concerned with the stability of structures provided by hydrogen bonds associated with the –CO-NH– peptide link. The Corey-Pauling rules state that: (1) All the atoms in the peptide link lie in the same plane.(2) The N, H, and O atoms in a hydrogen bond are approximately on a straight line.(3) All the CO and NH groups are involved in bonding. Two important structures in which the Corey-Pauling rules are obeyed are the alpha helix and the beta sheet.

(1) All the atoms in the peptide link lie in the same plane.

(2) The N, H, and O atoms in a hydrogen bond are approximately on a straight line.

(3) All the CO and NH groups are involved in bonding.

Subjects: Chemistry.


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