1. the simultaneous transformation of two or more bacterial genes; the genes cotransformed are inferred to be closely linked because transforming DNA fragments are usually small. Also called double transformation. 2. in molecular biology, introduction of two physically unlinked sets of genes, one of which codes for a selectable marker, into a cell. This technique is useful in animal cells in which the isolation of cells transformed with a gene that does not code for a selectable marker has been problematic.
Subjects: Genetics and Genomics.