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cotranslational transport


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The standard mechanism by which most proteins destined for secretion are translated in eukaryotic cells. The first part of the message (See signal sequence) is translated and causes the ribosome to become attached to the rough endoplasmic reticulum; subsequent translation causes the nascent polypeptide to move wholly or partially across the membrane into the intracisternal space. Proteins that are released into the lumen then progress through the GERL and are post-translationally modified in various ways.

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