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A multisubunit complex (cleavage and polyadenylation specificity factor) that binds the AAUAAA conserved sequence (cytoplasmic polyadenylation element) in pre-mRNA and is essential for splicing. Subunits range in size from CPSF-1 (1443 aa) to CPSF-5 (227 aa), with at least seven being involved, some recognizing RNA, others involved in cleavage and religation.

Subjects: Medicine and Health.

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