Crigler-Najjar syndrome

Show Summary Details

Quick Reference

A genetic disease in which the liver enzyme glucuronyl transferase, responsible for dealing with bilirubin, is absent. A large amount of unconjugated bilirubin accumulates in the blood and the syndrome presents in early childhood with worsening jaundice. The only definitive treatment is a liver transplant, without which life expectancy is usually less than two years. J. F. Crigler (1919) and V. A. Najjar (1914), US paediatricians

Subjects: Chemistry.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.