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Crigler-Najjar syndrome


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A genetic disease in which the liver enzyme glucuronyl transferase, responsible for dealing with bilirubin, is absent. A large amount of unconjugated bilirubin accumulates in the blood and the syndrome presents in early childhood with worsening jaundice. The only definitive treatment is a liver transplant, without which life expectancy is usually less than two years. J. F. Crigler (1919) and V. A. Najjar (1914), US paediatricians

Subjects: Chemistry.


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