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n. an abnormal protein – an immunoglobulin (see paraprotein) – that may be present in the blood in certain diseases. Cryoglobulins become insoluble at low temperatures, leading to obstruction of small blood vessels in the fingers and toes in cold weather and producing a characteristic rash. The presence of cryoglobulins (cryoglobulinaemia) may be a feature of a variety of diseases, including macroglobulinaemia, systemic lupus erythematosus, and certain infections.

Subjects: Medicine and Health.

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